Conclusions: Our results indicate that a Culture + PCR algorithm provides the optimal balance of cost and risk days averted at varying isolation, prevalence and screening coverage scenarios
Update: The confirmation and identification of suspect carbapenemases at North West London Pathology/ICNHT is now done by RESIST rather than PCR further reducing the cost per risk day averted for the preferred algorithm
Announcement of change from PCR to RESIST in the preferred screening algorithm :
Since the launch of several new products onto the market in 2017, Microbiology at NWLP have conducted an extensive evaluation of products currently available, testing time to result, accuracy, reproducibility, technical skill level required, cost and ease of workflow. A new testing pathway is currently being introduced with a live test of patient samples due to start imminently.
The new test being introduced is the Immunochromogenic lateral flow RESIST O.K.N test (Bioconnections), which can be performed on all enterobacteriaceae and will detect KPC, NDM and OXA48 direct from the screening agar – i.e. 90% of the confirmed CPEs detected to date..