the world's first rapid carbapenemase identification tests
RESIST OXA-48 and RESIST KPC
So accurate - So fast - So easy to use
Direct from a culture plate - the major carbapenemases can be identified in 15 minutes with accuracy matching the leading PCR systems and with no requirement for equipment
The kit contains cassettes, lysis buffer and tubes with dropper caps.
Add 10 drops of lysis buffer to a tube, select 1 colony with disposable loop, transfer into the lysis buffer tube & mix. Attach dropper cap and dispense 3 drops into the cassette well. Allow to react for 15 minutes and read the result.
Add 10 drops of lysis buffer to a tube, select 1 colony with disposable loop, transfer into the lysis buffer tube & mix. Attach dropper cap and dispense 3 drops into the cassette well. Allow to react for 15 minutes and read the result.
The Short History of RESIST
|
2015
2016 |
RESIST -OXA-48 launched
RESIST - KPC launched |
sensitivity 100% specificity 100%
sensitivity 100% specificity 100% |
|
2017
2018 |
RESIST -3 O.K.N. launched
(OXA, KPC, NDM) RESIST-4 O.K.N.V. launched (OXA, KPC, NDM, VIM) |
sensitivity 100% specificity 100%
VIM - sensitivity 100% specificity 100% |
KPC RESIST Publications OXA - 48 RESIST Publications
• Evaluation of the KPC K-SeT® immunochromatographic assay for the rapid detection of KPC carbapenemase producers from positive blood cultures.
Riccobono E, Antonelli A, Pecile P, Bogaerts P, D'Andrea MM, Rossolini GM.
J Antimicrob Chemother. 2018 Feb 1;73(2):539-540. doi: 10.1093/jac/dkx406.
In this work, we evaluated the performance of the KPC K-SeT® assay for the detection of KPC-type carbapenemases directly from positive blood cultures.
https://www.ncbi.nlm.nih.gov/pubmed/29126269
• Evaluation of a rapid immunochromatographic test for detection of distinct variants of Klebsiella pneumoniae carbapenemase (KPC) in Enterobacteriaceae.
Ramos AC, Gales AC, Monteiro J, Silbert S, Chagas-Neto T, Machado AMO, Carvalhaes CG.
J Microbiol Methods. 2017 Nov;142:1-3.
Abstract
The rapid detection of KPC-producing Enterobacteriaceae by microbiology laboratories has been required for infectious control programs. Herein we evaluated the performance of a novel immunochromatographic test for detecting KPC-2-, KPC-3-, KPC-4-, KPC-6-, KPC-7-, KPC-8-, and KPC-11-producing isolates and the influence of different growth media on the test performance.
http://www.sciencedirect.com/science/article/pii/S0167701217302245?via%3Dihub
• Comparison of the Novel Oxa-48 and Kpc K-SeT Assay, and Blue-Carba Test for the Detection of Carbapenemase-Producing Enterobacteriaceae Using PCR as a Reference Method.
Erdem F, Abulaila A, Aktas Z, Oncul O.
Clin Lab. 2017 Mar 1;63(3):515-522.
Abstract
BACKGROUND:
Rapid, simple, and accurate laboratory detection of carbapenemases is very important for proper antibiotic therapy and infection control.
METHODS:
In this study, carbapenem-nonsusceptible Enterobacteriaceae (CRE) isolates were used to evaluate the performance of a new lateral flow immunochromatographic (IC) assay, the OXA-48 and KPC K-SeT assay, and modified Blue-Carba test (BCT) for the rapid detection of OXA-48 carbapenemase in comparison with polymerase chain reaction (PCR) amplification. These CREs of various enterobacterial species were isolated from various clinical samples including OXA-48 (47), NDM-1 (6), KPC-1 (1), IMP-1 (1), VIM-2,-4 (2), IMP-2 (1), OXA-51 (1), and OXA-23 (1) producers.
RESULTS:
The OXA-48 K-SeT test detected all OXA-48 carbapenemase producers with 100% sensitivity and specificity. The BCT detected carbapenemase producers with 93% sensitivity and 100% specificity.
https://www.ncbi.nlm.nih.gov/pubmed/28271693
• Evaluation of the K-SeT R.E.S.I.S.T. immunochromatographic assay for the rapid detection of KPC and OXA-48-like carbapenemase.
Danièle Meunier, Anna Vickers, Rachel Pike, Robert L.Hill, Neil Woodford, Katie L. Hopkins.
J Antimicrob Chemother. 2016 April 26 doi:10.1093/jac/dkw113
J. Antimicrob. Chemother.-2016-Meunier-jac-dkw113
• Evaluation of two new commercial immunochromatographic assays for the rapid detection of OXA-48 and KPC carbapenemases from cultured bacteria.
Glupczynski Y, Evrard S, Ote I, Mertens P, Huang TD, Leclipteux T, Bogaerts P.
J Antimicrob Chemother. 2016 Jan 28. pii: dkv472. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/26825120
Abstract :
BACKGROUND:
Rapid detection and confirmation of carbapenemases remains very challenging for diagnostic laboratories.
OBJECTIVES:
The objective of this study was to assess the performance of two new immunochromatographic (IC) commercial assays for the rapid detection of OXA-48-producing and KPC-producing Enterobacteriaceae in pure bacterial isolates.
METHODS:
A panel of 92 bacterial isolates predominantly including carbapenem-non-susceptible Enterobacteriaceae with previously defined carbapenem resistance mechanisms was tested. Then, 342 consecutive carbapenem-non-susceptible Enterobacteriaceae isolates referred to the reference laboratory were investigated prospectively in parallel with other phenotypic tests and with multiplex PCR and sequencing as the gold standard.
RESULTS:
In the collection panel, each of the two IC assays correctly detected all 30 OXA-48-like-producing isolates and 25 KPC-producing isolates, whatever the species, their association with other β-lactamases and the level of resistance to carbapenems. All other carbapenemase producers and all non-carbapenemase-producing isolates yielded negative results with both tests. In the prospective evaluation, all OXA-48-like-producing Enterobacteriaceae isolates (n = 130) and KPC-producing Enterobacteriaceae isolates (n = 33) were correctly detected by the individual IC assays, while 179 non-OXA-48-like-producing and non-KPC-producing strains (137 non-carbapenemase producers and 42 isolates belonging to other carbapenemase family types) yielded negative results. Thus, each assay yielded 100% sensitivity and 100% specificity for the detection of OXA-48-like or KPC enzymes, respectively, at 15 min.
CONCLUSIONS:
The two IC assays allow rapid and reliable direct confirmation of OXA-48 and KPC carbapenemases from culture colonies and appear to be very useful additions to the existing tests, obviating the need for more costly characterization by molecular amplification methods.
• Development of a novel immunochromatographic combo test for rapid identification of OXA-48 and KPC carbapenemases in Enterobacteriaceae.
Borlon C, Denorme L, Evrard S, Ote I, Bogaerts P, Glupczynski Y, Mertens P
115th American Society for Microbiology May 30 - June 2, 2015 New Orleans
ASM-2015
• P0292 – Evaluation of five commercial confirmation tests for Carbapenemase-Producing
Enterobacteriaceaein an OXA-48 endemic geographic region.
C. Trouvé, R. De Smedt and E. De Laere
27th European Congress of Clinical Microbiology and Infectious Diseases, Infectious Diseases April 22 – 25, 2017
Poster
• EV0199 – Rapid and accurate detection of OXA-48 like carbapenemases in Enterobacteriaceae using the OXA-48 K-SeT kit.
F. Ismail, P. Meidany, M. Kock, M. Said, N. Mbelle and KA Strydom
27th European Congress of Clinical Microbiology and Infectious Diseases, Infectious Diseases April 22 – 25, 2017
Poster
• Evaluation of a rapid immunochromatographic test for the detection of OXA-48 carbapenemase.
Rubio E, Zboromyrska Y, Pitart C, Campo I, Alejo-Cancho I, Fasanella A, Vergara A, Marco F, Vila J.
Diagn Microbiol Infect Dis. 2017 Mar;87(3):266-267.
Abstract
We evaluated the OXA-48K-Set, a rapid immunochromatographic test for the detection of Oxacillinase-48 (OXA-48) carbapenemases, among 37 strains expressing OXA-48 and OXA-48-like carbapenemases and 20 additional strains harboring other β-lactamases. The test showed 100% sensitivity and specificity and the results were obtained in 15minutes.
https://www.ncbi.nlm.nih.gov/pubmed/27988171
• Comparison of phenotypic tests and an immunochromatographic assay and development of a new algorithm for OXA-48-like detection.
Koroska F, Göttig S, Kaase M, Steinmann J, Gatermann S, Sommer J, Wille T, Plum G1, Hamprecht A.
J Clin Microbiol. 2016 Dec 28. pii: JCM.01929-16. doi: 10.1128/JCM.01929-16. [Epub ahead of print]
Abstract
OXA-48 is the most prevalent carbapenemase in Enterobacteriaceae in Europe and the Middle East, but is frequently missed because many isolates display low minimal inhibitory concentrations (MIC) for carbapenems. Furthermore, in contrast to metallo-β-lactamases or Klebsiella pneumoniae carbapenemases (KPC), no specific inhibitor is available for the phenotypic detection of OXA-48. Molecular detection of blaOXA-48 is the gold standard, but is not available in many laboratories. Few phenotypic assays have been described, but have not been independently evaluated. The aim of this study was the systematic comparison of phenotypic tests and an immunochromatographic assay (ICT) for the detection of OXA-48/OXA-48-like carbapenemases and the development of an algorithm for reliable phenotypic detection of OXA-48.Four phenotypic tests (temocillin disk test, faropenem disk test, OXA-48 disk test and HI OXA-48 disk test) and a new ICT (OXA-48 K-SeT) were compared on a set of 166 Enterobacteriaceae isolates including OXA-48/OXA-48-like (n=84), Ambler class A and B carbapenemases (n=41), and carbapenemase-negative isolates (n=41).The sensitivity and specificity for the different assays was 100%/43.9% for temocillin, 57.1%/98.8% for faropenem, 53.6%/100% for the OXA-48 disk test, 98.8%/97.6% for the HI OXA-48 disk test and 100%/100% for the ICT, respectively.The ICT displayed the highest sensitivity and specificity, was the most rapid assay but is more costly than phenotypic assays. Based on these results, a new algorithm incorporating temocillin, faropenem and ICT was developed, which allows a cost-effective detection of OXA-48 with 100% sensitivity and specificity.
https://www.ncbi.nlm.nih.gov/pubmed/28031433
• P0946 - The Coris BioConcept OXA48 K-SeT Immuno-Chromatographic Assay Detects OXA48-type Carbapenemases with High Sensitivity and Specificity.
B.M. Willey, X. Trimi, R. Ioboni, D.A. Boyd, G. Ricci, D.N. Grohn, D. Terenzi, A. Mazzulli, L. Mataseje, M. Mulvey, P. Lo, T. Mazzulli, S.M. Poutanen
26th European Congress of Clinical Microbiology and Infectious Diseases, Infectious Diseases April 09 – 12, 2016
Poster946
• Evaluation of OXA-48 K-SeT: an immunochromatographic assay for rapid detection of OXA-48-producing enteriobacteriaceae.
Fernandez J, Fleites A, Rodcio MR, Vazquez F.
Diagn Micribiol Infect Dis. 2016 Jan 26. pii: S0732-8893(16)00034-1. doi: 10.1016/j.diagmicrobio.2016.01.015. [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/pubmed/26971639
• Prospective evaluation of the OXA-48 K-SeT assay, an immunochromatographic test for the rapid detection of OXA-48-type carbapenemases.
Dortet L, Jousset A, Sainte-Rose V, Cuzon G, Naas T.
J Antimicrob Chemother. 2016 Mar 10. pii: [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/pubmed/26968882
• Evaluation of an Immunochromatographic Lateral Flow Assay (OXA-48 K-SeT) for the Rapid Detection of OXA-48-like Carbapenemases in Enterobacteriaceae.
Wareham DW, Shah R, Betts JW, Phee LM, Abdul Momin MH.
J Clin Microbiol. 2015 Nov 25. pii: JCM.02900-15.
http://www.ncbi.nlm.nih.gov/pubmed/26607983
Abstract :
We evaluated an immunochromatographic lateral flow assay for the detection of OXA-48-like carbapenemases (OXA-48 K-SeT) in Enterobacteriaceae (n=82). 100% sensitivity and specificity was observed using bacteria recovered from both solid media and spiked blood culture bottles, with the result obtained in less than 10 minutes.
• Development of a novel immunochromatographic confirmatory test for the detection of OXA-48 carbapenemase in Enterobacteriaceae.
Isabelle Ote, Pierre Bogaerts, Laurence Denorme, Céline Borlon, Caroline Thunissen, Youri Glupczynski, Thierry Leclipteux, Pascal Mertens.
25th European Congress of Clinical Microbiology and Infectious Diseases April-25 - 28, 2015
Development of a novel...
ECCMID presentation - Isabelle OTE
• Evaluation of the KPC K-SeT® immunochromatographic assay for the rapid detection of KPC carbapenemase producers from positive blood cultures.
Riccobono E, Antonelli A, Pecile P, Bogaerts P, D'Andrea MM, Rossolini GM.
J Antimicrob Chemother. 2018 Feb 1;73(2):539-540. doi: 10.1093/jac/dkx406.
In this work, we evaluated the performance of the KPC K-SeT® assay for the detection of KPC-type carbapenemases directly from positive blood cultures.
https://www.ncbi.nlm.nih.gov/pubmed/29126269
• Evaluation of a rapid immunochromatographic test for detection of distinct variants of Klebsiella pneumoniae carbapenemase (KPC) in Enterobacteriaceae.
Ramos AC, Gales AC, Monteiro J, Silbert S, Chagas-Neto T, Machado AMO, Carvalhaes CG.
J Microbiol Methods. 2017 Nov;142:1-3.
Abstract
The rapid detection of KPC-producing Enterobacteriaceae by microbiology laboratories has been required for infectious control programs. Herein we evaluated the performance of a novel immunochromatographic test for detecting KPC-2-, KPC-3-, KPC-4-, KPC-6-, KPC-7-, KPC-8-, and KPC-11-producing isolates and the influence of different growth media on the test performance.
http://www.sciencedirect.com/science/article/pii/S0167701217302245?via%3Dihub
• Comparison of the Novel Oxa-48 and Kpc K-SeT Assay, and Blue-Carba Test for the Detection of Carbapenemase-Producing Enterobacteriaceae Using PCR as a Reference Method.
Erdem F, Abulaila A, Aktas Z, Oncul O.
Clin Lab. 2017 Mar 1;63(3):515-522.
Abstract
BACKGROUND:
Rapid, simple, and accurate laboratory detection of carbapenemases is very important for proper antibiotic therapy and infection control.
METHODS:
In this study, carbapenem-nonsusceptible Enterobacteriaceae (CRE) isolates were used to evaluate the performance of a new lateral flow immunochromatographic (IC) assay, the OXA-48 and KPC K-SeT assay, and modified Blue-Carba test (BCT) for the rapid detection of OXA-48 carbapenemase in comparison with polymerase chain reaction (PCR) amplification. These CREs of various enterobacterial species were isolated from various clinical samples including OXA-48 (47), NDM-1 (6), KPC-1 (1), IMP-1 (1), VIM-2,-4 (2), IMP-2 (1), OXA-51 (1), and OXA-23 (1) producers.
RESULTS:
The OXA-48 K-SeT test detected all OXA-48 carbapenemase producers with 100% sensitivity and specificity. The BCT detected carbapenemase producers with 93% sensitivity and 100% specificity.
https://www.ncbi.nlm.nih.gov/pubmed/28271693
• Evaluation of the K-SeT R.E.S.I.S.T. immunochromatographic assay for the rapid detection of KPC and OXA-48-like carbapenemase.
Danièle Meunier, Anna Vickers, Rachel Pike, Robert L.Hill, Neil Woodford, Katie L. Hopkins.
J Antimicrob Chemother. 2016 April 26 doi:10.1093/jac/dkw113
J. Antimicrob. Chemother.-2016-Meunier-jac-dkw113
• Evaluation of two new commercial immunochromatographic assays for the rapid detection of OXA-48 and KPC carbapenemases from cultured bacteria.
Glupczynski Y, Evrard S, Ote I, Mertens P, Huang TD, Leclipteux T, Bogaerts P.
J Antimicrob Chemother. 2016 Jan 28. pii: dkv472. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/26825120
Abstract :
BACKGROUND:
Rapid detection and confirmation of carbapenemases remains very challenging for diagnostic laboratories.
OBJECTIVES:
The objective of this study was to assess the performance of two new immunochromatographic (IC) commercial assays for the rapid detection of OXA-48-producing and KPC-producing Enterobacteriaceae in pure bacterial isolates.
METHODS:
A panel of 92 bacterial isolates predominantly including carbapenem-non-susceptible Enterobacteriaceae with previously defined carbapenem resistance mechanisms was tested. Then, 342 consecutive carbapenem-non-susceptible Enterobacteriaceae isolates referred to the reference laboratory were investigated prospectively in parallel with other phenotypic tests and with multiplex PCR and sequencing as the gold standard.
RESULTS:
In the collection panel, each of the two IC assays correctly detected all 30 OXA-48-like-producing isolates and 25 KPC-producing isolates, whatever the species, their association with other β-lactamases and the level of resistance to carbapenems. All other carbapenemase producers and all non-carbapenemase-producing isolates yielded negative results with both tests. In the prospective evaluation, all OXA-48-like-producing Enterobacteriaceae isolates (n = 130) and KPC-producing Enterobacteriaceae isolates (n = 33) were correctly detected by the individual IC assays, while 179 non-OXA-48-like-producing and non-KPC-producing strains (137 non-carbapenemase producers and 42 isolates belonging to other carbapenemase family types) yielded negative results. Thus, each assay yielded 100% sensitivity and 100% specificity for the detection of OXA-48-like or KPC enzymes, respectively, at 15 min.
CONCLUSIONS:
The two IC assays allow rapid and reliable direct confirmation of OXA-48 and KPC carbapenemases from culture colonies and appear to be very useful additions to the existing tests, obviating the need for more costly characterization by molecular amplification methods.
• Development of a novel immunochromatographic combo test for rapid identification of OXA-48 and KPC carbapenemases in Enterobacteriaceae.
Borlon C, Denorme L, Evrard S, Ote I, Bogaerts P, Glupczynski Y, Mertens P
115th American Society for Microbiology May 30 - June 2, 2015 New Orleans
ASM-2015
• P0292 – Evaluation of five commercial confirmation tests for Carbapenemase-Producing
Enterobacteriaceaein an OXA-48 endemic geographic region.
C. Trouvé, R. De Smedt and E. De Laere
27th European Congress of Clinical Microbiology and Infectious Diseases, Infectious Diseases April 22 – 25, 2017
Poster
• EV0199 – Rapid and accurate detection of OXA-48 like carbapenemases in Enterobacteriaceae using the OXA-48 K-SeT kit.
F. Ismail, P. Meidany, M. Kock, M. Said, N. Mbelle and KA Strydom
27th European Congress of Clinical Microbiology and Infectious Diseases, Infectious Diseases April 22 – 25, 2017
Poster
• Evaluation of a rapid immunochromatographic test for the detection of OXA-48 carbapenemase.
Rubio E, Zboromyrska Y, Pitart C, Campo I, Alejo-Cancho I, Fasanella A, Vergara A, Marco F, Vila J.
Diagn Microbiol Infect Dis. 2017 Mar;87(3):266-267.
Abstract
We evaluated the OXA-48K-Set, a rapid immunochromatographic test for the detection of Oxacillinase-48 (OXA-48) carbapenemases, among 37 strains expressing OXA-48 and OXA-48-like carbapenemases and 20 additional strains harboring other β-lactamases. The test showed 100% sensitivity and specificity and the results were obtained in 15minutes.
https://www.ncbi.nlm.nih.gov/pubmed/27988171
• Comparison of phenotypic tests and an immunochromatographic assay and development of a new algorithm for OXA-48-like detection.
Koroska F, Göttig S, Kaase M, Steinmann J, Gatermann S, Sommer J, Wille T, Plum G1, Hamprecht A.
J Clin Microbiol. 2016 Dec 28. pii: JCM.01929-16. doi: 10.1128/JCM.01929-16. [Epub ahead of print]
Abstract
OXA-48 is the most prevalent carbapenemase in Enterobacteriaceae in Europe and the Middle East, but is frequently missed because many isolates display low minimal inhibitory concentrations (MIC) for carbapenems. Furthermore, in contrast to metallo-β-lactamases or Klebsiella pneumoniae carbapenemases (KPC), no specific inhibitor is available for the phenotypic detection of OXA-48. Molecular detection of blaOXA-48 is the gold standard, but is not available in many laboratories. Few phenotypic assays have been described, but have not been independently evaluated. The aim of this study was the systematic comparison of phenotypic tests and an immunochromatographic assay (ICT) for the detection of OXA-48/OXA-48-like carbapenemases and the development of an algorithm for reliable phenotypic detection of OXA-48.Four phenotypic tests (temocillin disk test, faropenem disk test, OXA-48 disk test and HI OXA-48 disk test) and a new ICT (OXA-48 K-SeT) were compared on a set of 166 Enterobacteriaceae isolates including OXA-48/OXA-48-like (n=84), Ambler class A and B carbapenemases (n=41), and carbapenemase-negative isolates (n=41).The sensitivity and specificity for the different assays was 100%/43.9% for temocillin, 57.1%/98.8% for faropenem, 53.6%/100% for the OXA-48 disk test, 98.8%/97.6% for the HI OXA-48 disk test and 100%/100% for the ICT, respectively.The ICT displayed the highest sensitivity and specificity, was the most rapid assay but is more costly than phenotypic assays. Based on these results, a new algorithm incorporating temocillin, faropenem and ICT was developed, which allows a cost-effective detection of OXA-48 with 100% sensitivity and specificity.
https://www.ncbi.nlm.nih.gov/pubmed/28031433
• P0946 - The Coris BioConcept OXA48 K-SeT Immuno-Chromatographic Assay Detects OXA48-type Carbapenemases with High Sensitivity and Specificity.
B.M. Willey, X. Trimi, R. Ioboni, D.A. Boyd, G. Ricci, D.N. Grohn, D. Terenzi, A. Mazzulli, L. Mataseje, M. Mulvey, P. Lo, T. Mazzulli, S.M. Poutanen
26th European Congress of Clinical Microbiology and Infectious Diseases, Infectious Diseases April 09 – 12, 2016
Poster946
• Evaluation of OXA-48 K-SeT: an immunochromatographic assay for rapid detection of OXA-48-producing enteriobacteriaceae.
Fernandez J, Fleites A, Rodcio MR, Vazquez F.
Diagn Micribiol Infect Dis. 2016 Jan 26. pii: S0732-8893(16)00034-1. doi: 10.1016/j.diagmicrobio.2016.01.015. [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/pubmed/26971639
• Prospective evaluation of the OXA-48 K-SeT assay, an immunochromatographic test for the rapid detection of OXA-48-type carbapenemases.
Dortet L, Jousset A, Sainte-Rose V, Cuzon G, Naas T.
J Antimicrob Chemother. 2016 Mar 10. pii: [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/pubmed/26968882
• Evaluation of an Immunochromatographic Lateral Flow Assay (OXA-48 K-SeT) for the Rapid Detection of OXA-48-like Carbapenemases in Enterobacteriaceae.
Wareham DW, Shah R, Betts JW, Phee LM, Abdul Momin MH.
J Clin Microbiol. 2015 Nov 25. pii: JCM.02900-15.
http://www.ncbi.nlm.nih.gov/pubmed/26607983
Abstract :
We evaluated an immunochromatographic lateral flow assay for the detection of OXA-48-like carbapenemases (OXA-48 K-SeT) in Enterobacteriaceae (n=82). 100% sensitivity and specificity was observed using bacteria recovered from both solid media and spiked blood culture bottles, with the result obtained in less than 10 minutes.
• Development of a novel immunochromatographic confirmatory test for the detection of OXA-48 carbapenemase in Enterobacteriaceae.
Isabelle Ote, Pierre Bogaerts, Laurence Denorme, Céline Borlon, Caroline Thunissen, Youri Glupczynski, Thierry Leclipteux, Pascal Mertens.
25th European Congress of Clinical Microbiology and Infectious Diseases April-25 - 28, 2015
Development of a novel...
ECCMID presentation - Isabelle OTE
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