RESIST-5 O.O.K.N.V. + I. This new immunochromatography test allows the identification of the following carbapenemases: OXA-48-like, KPC, NDM IMP and VIM carbapenemases from culture. It also differentiates the non-carbapenemase OXA variants (OXA-163 like) from the carbapenemase producing OXA-48 like
Why is OXA-163 important?
Some OXA-48 detection/identification products, both commercial PCR and lateral flow, do not discriminate between carbapenemase producing and non-carbapenemase producing OXA variants.
OXA-48 variants have medium or high carbapenemase activity. They are often susceptible to expanded-spectrum cephalosporins but resistant to carbapenems.
OXA-163 variants have little or no carbapenemase activity. They are often resistant to expanded-spectrum cephalosporins but susceptible to carbapenems.
Some OXA-48 detection/identification products, both commercial PCR and lateral flow, do not discriminate between carbapenemase producing and non-carbapenemase producing OXA variants.
OXA-48 variants have medium or high carbapenemase activity. They are often susceptible to expanded-spectrum cephalosporins but resistant to carbapenems.
OXA-163 variants have little or no carbapenemase activity. They are often resistant to expanded-spectrum cephalosporins but susceptible to carbapenems.
Whilst treatment should be guided by susceptibility results it is advantageous to have insight into the antibiotic groups that may or may not be affected by the beta-lactamases present.
This chart shows the resistance levels to be expected from various carbapenemases. It highlights that whilst OXA-48 may be treated with 3rd & 4th generation carbapenems OXA-163 cannot; yet can be treated with some carbapenems.
RESIST-5 O.O.K.N.V. + I. consists of two cassettes. One cassette for NDM + IMP + VIM and the other for OXA-48 + OXA 163 + KPC. This chart shows the variants that are recognised.
RESIST-5 O.O.K.N.V. + I. components have the extremely high sensitivity and specificity associated with other products in the RESIST range.
