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Streptococcus pneumoniae
resistance & M.I.C.

Streptococcus pneumoniae no longer has predictable antibiotic susceptibility. Strains with low-level penicillin  resistance still respond to penicillin in respiratory tract infections and bacteraemia, but not in meningitis. 
Where Oxacillin 1 µg is used as a screen for beta-lactam resistance EUCAST recommends an MIC is obtained where the zone is  <20mm
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EUCAST

Antibiotic Panel
 
Amoxycillin/Clavulanate
Ampicillin
Bacitracin
Ceftriaxon
Cefuroxim
Ciprofloxacin
Clarithromycin
Clindamycin
Colistin
Doxycyclin
Erythromycin
Imipenem
Moxifloxacin
Penicillin G
 
MIC for all except colistin & bacitracin

PRODUCT FILE

pneumohinfl_001.pdf
File Size:	714 kb
File Type:	pdf

Download File

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H. influenzae & broth microdilution
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Comparative testing between  BMD and gradient diffusion testing  has highlighted concerns about the reliability of gradient diffusion tests for determining the MIC of H. influenza
A EUCAST poster at ECCMID 2016 stated he correlation between gradient test MICs and BMD is poor  for some antibiotics
P805 ECCMID 2016 

ECCMID POster