The Coris Bioconcept RESIST range of carbapenemase immunochromatographic identification tests
The first immunochromatography tests to identify carbapenemase phenotypes,
gives results from culture in 15 minutes.
Patented in 2016 (WO 2016162564 A1) the process is a rapid and accurate way of identifying carbapenemases.
All products in the RESIST range are CE marked.
OXA-48 K-SeT was launched at ECCMID 2015 with presentations that support its efficacy. Subsequent UK evaluations have confirmed 100% sensitivity and specificity
KPC K-SeT was launched in August 2015, U.K & European evaluations confirm 100% sensitivity and specificity
RESIST-3 O.K.N. K-Set launched in November 2016 brings together OXA-48 & KPC K-sets and adds NDM to produce a product that covers 95% of isolated .carbapenemases in the UK. The first published evaluation of RESIST-3 confirms 100% sensitivity and specificity.
RESIST-4 O.K.N.V. K-Set launched in February 2018 adds VIM to the successful RESIST-3 O.K.N. kit. The kit covers over 98% of carbapenemases according to the PHE AMRHAI data updated October 2016
https://Screening for CPEs - Which approach
In a recent publication results indicate that a Culture + PCR algorithm provides the optimal balance of cost and risk days averted at varying isolation, prevalence and screening coverage scenarios. The hospital at the heart of this publication has now changed from PCR to RESIST for both financila and workflow reasons.
Fast and expensive (PCR) or cheap and slow (culture)? A mathematical modelling study to explore screening for carbapenem resistance in UK hospitals
Announcement of change from PCR to RESIST in the preferred screening algorithm :
Since the launch of several new products onto the market in 2017, Microbiology at NWLP have conducted an extensive evaluation of products currently available, testing time to result, accuracy, reproducibility, technical skill level required, cost and ease of workflow. A new testing pathway is currently being introduced with a live test of patient samples due to start imminently.
The new test being introduced is the Immunochromogenic lateral flow RESIST O.K.N test (Bioconnections), which can be performed on all enterobacteriaceae and will detect KPC, NDM and OXA48 direct from the screening agar – i.e. 90% of the confirmed CPEs detected to date..
ICHNT/NWLP carbapenemase method change announcement
A useful article just published (online) in Pathology in Practice
read the article from the Royal Free Hospital published on RESIST OKN published in Pathology in Practice