RESIST IMP - launching October 2019
RESIST IMP Rapid and Easy-to-use
Like all products in Coris' RESIST range RESIST IMP is a lateral flow immunoassay detecting specific molecules of a carbapenemase in under 15 minutes.
1 The test organism is homogenized into the lysis buffer in the provided test tube
2 A dropper cap is connected and 3 drops of the treated sample are added to the sample well of the cassette
3 Results are read within 15 minutes.
Like all products in Coris' RESIST range RESIST IMP is a lateral flow immunoassay detecting specific molecules of a carbapenemase in under 15 minutes.
1 The test organism is homogenized into the lysis buffer in the provided test tube
2 A dropper cap is connected and 3 drops of the treated sample are added to the sample well of the cassette
3 Results are read within 15 minutes.
How good are current rapid products at recognising IMP carbapenemases?
Publications have shown wide variance in sensitivity
NG Carba5 - 55% 75% - ref 1, ref 2
Cepheid - 44% 71% - ref 1, ref 3
The new RESIST IMP has 97%* sensitivity
*The RESIST figure is work done on a collection of 94 fully-characterised IMP strains at the National Reference Laboratory for MDR Gram Negatives (Belgium) and University Hospital Brussels.
So why the wide differences in sensitivity?
There are 70+ IMP variants, antibodies have to be raised to epitopes which are common to a number of variants. The chosen epitope, used to raise an antibody for use in a diagnostic test, will be present in a wide range of variants. It is important that the key variants (decided by frequency and geography) are covered.
References
1 Evaluation of the NG-Test CARBA 5 multiplex immunochromatographic assay for the detection of KPC, OXA-48-like, NDM, VIM and IMP carbapenemases
Katie L Hopkins, Danièle Meunier, Thierry Naas, Hervé Volland, Neil Woodford
Journal of Antimicrobial Chemotherapy, doi.org/10.1093/jac/dky342
Published: 05 September 2018
2 Comparison of five methods for detection of carbapenemases in Enterobacterales with proposal of a new algorithm
L. Lucena Baeza1, N. Pfennigwerth2, C. Greissl1, S. Göttig3, A. Saleh1, Y. Stelzer1, S.G. Gatermann2, A. Hamprecht1,4,
doi.org/10.1016/j.cmi.2019.03.003
3 Evaluation of three commercial assays for rapid detection of genes encoding clinically relevant carbapenemases in cultured bacteria.
Jacqueline Findlay, Katie L. Hopkins, Daniele Meunier and Neil Woodford*
J Antimicrob Chemother doi:10.1093/jac/dku571
Publications have shown wide variance in sensitivity
NG Carba5 - 55% 75% - ref 1, ref 2
Cepheid - 44% 71% - ref 1, ref 3
The new RESIST IMP has 97%* sensitivity
*The RESIST figure is work done on a collection of 94 fully-characterised IMP strains at the National Reference Laboratory for MDR Gram Negatives (Belgium) and University Hospital Brussels.
So why the wide differences in sensitivity?
There are 70+ IMP variants, antibodies have to be raised to epitopes which are common to a number of variants. The chosen epitope, used to raise an antibody for use in a diagnostic test, will be present in a wide range of variants. It is important that the key variants (decided by frequency and geography) are covered.
References
1 Evaluation of the NG-Test CARBA 5 multiplex immunochromatographic assay for the detection of KPC, OXA-48-like, NDM, VIM and IMP carbapenemases
Katie L Hopkins, Danièle Meunier, Thierry Naas, Hervé Volland, Neil Woodford
Journal of Antimicrobial Chemotherapy, doi.org/10.1093/jac/dky342
Published: 05 September 2018
2 Comparison of five methods for detection of carbapenemases in Enterobacterales with proposal of a new algorithm
L. Lucena Baeza1, N. Pfennigwerth2, C. Greissl1, S. Göttig3, A. Saleh1, Y. Stelzer1, S.G. Gatermann2, A. Hamprecht1,4,
doi.org/10.1016/j.cmi.2019.03.003
3 Evaluation of three commercial assays for rapid detection of genes encoding clinically relevant carbapenemases in cultured bacteria.
Jacqueline Findlay, Katie L. Hopkins, Daniele Meunier and Neil Woodford*
J Antimicrob Chemother doi:10.1093/jac/dku571
|
|
|
