RESIST IMP - launched October 2019
The RESIST IMP offers a significant improvement in the sensitivity of IMP detection in rapid carbapenemase tests.
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*The new RESIST IMP has a 97% sensitivity based on work done using 94 fully-characterised IMP strains at the Belgium National Reference Laboratory-Namur and University Hospital-Brussels.
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How good are current rapid products at recognising IMP carbapenemases?
Publications have shown wide variance in sensitivity
NG Carba5 - 55% 75% - ref 1, ref 2
Cepheid - 44% 71% - ref 1, ref 3
The new RESIST IMP has 97%* sensitivity
*The RESIST figure is work done on a collection of 94 fully-characterised IMP strains at the National Reference Laboratory for MDR Gram Negatives (Belgium) and University Hospital Brussels.
So why the wide differences in sensitivity?
There are 70+ IMP variants, antibodies have to be raised to epitopes which are common to a number of variants. The chosen epitope, used to raise an antibody for use in a diagnostic test, will be present in a wide range of variants. It is important that the key variants (decided by frequency and geography) are covered.
How many variants does my current IMP test detect?
This information could be on the documents supplied with a product that claims to detect IMP or can be gleaned from published evaluations.
RESIST IMP detects 19 variants which is significantly more than its competitors.
References
1 Evaluation of the NG-Test CARBA 5 multiplex immunochromatographic assay for the detection of KPC, OXA-48-like, NDM, VIM and IMP carbapenemases
Katie L Hopkins, Danièle Meunier, Thierry Naas, Hervé Volland, Neil Woodford
Journal of Antimicrobial Chemotherapy, doi.org/10.1093/jac/dky342
Published: 05 September 2018
2 Comparison of five methods for detection of carbapenemases in Enterobacterales with proposal of a new algorithm
L. Lucena Baeza1, N. Pfennigwerth2, C. Greissl1, S. Göttig3, A. Saleh1, Y. Stelzer1, S.G. Gatermann2, A. Hamprecht1,4,
doi.org/10.1016/j.cmi.2019.03.003
3 Evaluation of three commercial assays for rapid detection of genes encoding clinically relevant carbapenemases in cultured bacteria.
Jacqueline Findlay, Katie L. Hopkins, Daniele Meunier and Neil Woodford*
J Antimicrob Chemother doi:10.1093/jac/dku571
Publications have shown wide variance in sensitivity
NG Carba5 - 55% 75% - ref 1, ref 2
Cepheid - 44% 71% - ref 1, ref 3
The new RESIST IMP has 97%* sensitivity
*The RESIST figure is work done on a collection of 94 fully-characterised IMP strains at the National Reference Laboratory for MDR Gram Negatives (Belgium) and University Hospital Brussels.
So why the wide differences in sensitivity?
There are 70+ IMP variants, antibodies have to be raised to epitopes which are common to a number of variants. The chosen epitope, used to raise an antibody for use in a diagnostic test, will be present in a wide range of variants. It is important that the key variants (decided by frequency and geography) are covered.
How many variants does my current IMP test detect?
This information could be on the documents supplied with a product that claims to detect IMP or can be gleaned from published evaluations.
RESIST IMP detects 19 variants which is significantly more than its competitors.
References
1 Evaluation of the NG-Test CARBA 5 multiplex immunochromatographic assay for the detection of KPC, OXA-48-like, NDM, VIM and IMP carbapenemases
Katie L Hopkins, Danièle Meunier, Thierry Naas, Hervé Volland, Neil Woodford
Journal of Antimicrobial Chemotherapy, doi.org/10.1093/jac/dky342
Published: 05 September 2018
2 Comparison of five methods for detection of carbapenemases in Enterobacterales with proposal of a new algorithm
L. Lucena Baeza1, N. Pfennigwerth2, C. Greissl1, S. Göttig3, A. Saleh1, Y. Stelzer1, S.G. Gatermann2, A. Hamprecht1,4,
doi.org/10.1016/j.cmi.2019.03.003
3 Evaluation of three commercial assays for rapid detection of genes encoding clinically relevant carbapenemases in cultured bacteria.
Jacqueline Findlay, Katie L. Hopkins, Daniele Meunier and Neil Woodford*
J Antimicrob Chemother doi:10.1093/jac/dku571
RESIST IMP Rapid and Easy-to-use
Like all products in Coris' RESIST range RESIST IMP is a lateral flow immunoassay detecting specific molecules of a carbapenemase in under 15 minutes.
1 The test organism is homogenized into the lysis buffer in the provided test tube
2 A dropper cap is connected and 3 drops of the treated sample are added to the sample well of the cassette
3 Results are read within 15 minutes.
Like all products in Coris' RESIST range RESIST IMP is a lateral flow immunoassay detecting specific molecules of a carbapenemase in under 15 minutes.
1 The test organism is homogenized into the lysis buffer in the provided test tube
2 A dropper cap is connected and 3 drops of the treated sample are added to the sample well of the cassette
3 Results are read within 15 minutes.
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